Indian J Pediatr. 2012 Mar;79(3):327-32. doi: 10.1007/s y. Epub 2011 Jun 29. Intravenous diazepam, midazolam and lorazepam in acute seizure control. Gathwala G(1), Goel M, Singh J, Mittal K. Author information: (1)Departments of Pediatrics, Pt. B.D.Sharma PGIMS, University of Health Sciences Rohtak.
The primary outcome was the time to seizure cessation and secondary outcome was the side effects of the drugs. One hundred and twenty children of either sex in the age group 6 month to 14 years brought convulsing to the pediatric emergency services, were enrolled in the study. The patient's vitals were monitored and recorded in a predesigned performa. End of seizure episode (clinically) was defined as cessation of visible epileptic phenomenon or return of purposeful response to external stimuli within 15 min of drug administration.
Lorazepam = 1 mg (anxiolytic/anticonvulsant; onset/time to peak: 2-4 hrs; 10-20 hr half life) Lormetazepam = 1 mg (hypnotic; onset/time to peak: 0.5-2 hrs; 10-12 hr half life) Medazepam = 10 mg (anxiolytic; onset/time to peak: 2-6 hrs; 36-200 hr half life) Midazolam = 5-8 mg (hypnotic/anticonvulsant;.
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Day 11: Discontinue methadone. Conversion of continuous intravenous midazolam >7 d duration to enteral lorazepam: 1. By using the current hourly infusion rate, calculate the 24-h midazolam dose. 2. Because lorazepam is twice as potent as midazolam and has a sixfold longer half-life, divide the 24 h midazolam dose by.
Weaning Protocols by Using Conversion of Continuous Opioid Infusions to Enteral Methadone and for Conversion of Midazolam (Versed) Infusion to Enteral Lorazepam (Ativan).
Lorazepam can therefore act as a bridge till the diazepam dosage is established. If patient is requiring multiple. PRN's then MD needs to be notified and diazepam should be increased. The PRN dose of Lorazepam should be ceased after 48 hours. Conversion of IV Midazolam to IV or PO Diazepam: 1) Calculate the total.
Page 1. January 2013. Diazepam (Valium), lorazepam (Ativan), and midazolam (Versed), the three injectable. Note: There are no direct dosage conversions between the benzodiazepines because each has a distinct. Drug. • ALL INJECTABLE. • Oral dosage forms available. • ALL INJECTABLE product. • All oral dosage forms.