Peak plasma concentrations occur after 2 to 3 hours when promethazine is administered orally (25 to 50 mg) or intramuscularly (25 mg). Following rectal administration of promethazine in a suppository formulation, peak plasma concentrations were observed after about 8 hours. Oral bioavailability is.
Many of the signs and symptoms of poisoning are similar to those observed with atropine. Hypotension and extrapyramidal signs may be attributable to antidopaminergic actions of promethazine. Most reference texts suggest that the toxicity of promethazine is mainly due to its anticholinergic actions at muscarinic receptors. Besides anticholinergic 5 effects, promethazine can also exhibit toxic effects typical of antipsychotic phenothiazines. In the presence of anticholinergic effects, serious manifestations such as seizures, hallucinations, hypertension, and arrhythmias have been reversed by the administration of physostigmine.
Remain lying down for a few minutes after using this medication, and avoid having a bowel movement for an hour or longer so the drug will be absorbed. The suppository is for rectal use only.For motion sickness, the first dose of promethazine should be used 30 to 60 minutes before beginning travel.
Psoriasis See What It Looks Like and How to Treat It.
Tinnitus Slideshow: Why Are My Ears Ringing?
Read more: Vertigo and Balance Disorders Quiz: Test Your Medical IQ.
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching /swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Balance Disorders Slideshow. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects.
Remain lying down for a few minutes after using this medication, and avoid having a bowel movement for an hour or longer so the drug will be absorbed. The suppository is for rectal use only. For motion sickness, the first dose of promethazine should be used 30 to 60 minutes before beginning travel.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
See also Warning section.
Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages. This drug may make you dizzy or drowsy or cause blurred vision.
Limit your time in the sun. Avoid tanning booths and sunlamps. This medication may make you more sensitive to the sun.
To insert suppository: First remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum. If the suppository is too soft to insert, chill the suppository in the refrigerator for 30 minutes or run cold water over it.
Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. 2017 Truven Health Analytics Inc.
Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.
Drug information provided by: Micromedex.
Do not keep outdated medicine or medicine no longer needed.
Never take rectal suppositories by mouth.
Subscribe to Housecall.
Do not double doses. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Wash your hands with soap and water before and after using this medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
The suppository form is used when medications cannot be taken by mouth. Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting.
Promethazine is an antihistamine and works by blocking a certain natural substance ( histamine ) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine ) and by acting directly on certain parts of the brain.
Next: What Are Side Effects Associated with Using Promethazine?
Adult Dosage Forms and Strengths Tablet Suppository Injectable solution Syrup.
Promethazine is available under the following different brand names: Phenergan, and Phenadoz. Dosage of Promethazine:.
See additional information. RxList does not provide medical advice, diagnosis or treatment. 2017 by RxList Inc.
It is also used to treat allergy symptoms such as rash, itching, and runny nose. The suppository form is used when medications cannot be taken by mouth. It may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better. Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as motion sickness, or before/after surgery).
What Is Promethazine and How Does It Work?
Get the latest treatment options.
Dosing Consideraations – Should be Given as Follows: Allergic Conditions Nausea and Vomiting Motion Sickness Preoperative Sedation Postoperative Sedation Obstetric Sedation Allergic Conditions (Off-label) Nausea & Vomiting Motion Sickness Sedation Preoperative Sedation Postoperative Sedation.