Oral lorazepam in the dose of 0.5–1 mg may be given 1–2 hours before or 30–60 minutes before the dental procedure for the sublingual preparation. Diazepam has a long half-life which is further extended in elderly patients; thus, its use in these individuals is not recommended. The antihistamines are typically longer acting.
It was soon discovered that chloral hydrate worked more quickly in combination with alcohol and, when slipped into whiskey, it was the “knockout drops” of the underworld, also called a “Mickey Finn.”. Chloral hydrate (Noctec) was synthesized in 1832 by the German chemist, Justus von Liebig, and represented the first class of sedative agents to show longevity on the mainstream pharmacopeia. Chloral hydrate is a generalized CNS depressant that acts rapidly, and if given alone, is capable of inducing deep sleep in approximay 30 minutes.
Furthermore, their effects can be reversed using the benzodiazepine antagonist, flumazenil.
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After I took klonopin some years ago I started to use all benzo's sublingually. Now I'm sitting here with a Valium waiting to dissolve under my.
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klonopin is delicious and kicks in in like 45 minutes instead of an hour or so, clonazolam is a bit bitter but tolerable and kicks in very quickly as well. like 15 minutes as oppoosed to 30 min. but sometimes i just swallow em too, doesn't relaly matter all that much. i dont do it with xanax because it hits you hard enough in like 5 minutes.
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After I took klonopin some years ago I started to use all benzo's sublingually.
Summary. We gave 12 healthy male volunteers 1 mg of alprazolam or placebo on three occasions after a standard breakfast in a double-blind, randomized, single-dose, three-way crossover study. The three trials were: (a) oral alprazolam and sublingual placebo; (b) oral placebo and sublingual alprazolam; placebo by.
The three trials were: (a) oral alprazolam and sublingual placebo; (b) oral placebo and sublingual alprazolam; placebo by both routes.
Plasma alprazolam concentrations during 24 h after each dose were measured by electron-capture gas-liquid chromatography.
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We gave 12 healthy male volunteers 1 mg of alprazolam or placebo on three occasions after a standard breakfast in a double-blind, randomized, single-dose, three-way crossover study.
Other kinetic variables were not significantly different: peak plasma concentration, 11.3 vs 12.0 ng·ml−1; elimination half-life, 12.5 vs 11.7 h; and total area under the plasma concentration versus time curve, 197 vs 186 h·ng·ml−1. Peak plasma concentrations were reached later after sublingual than oral dosage (2.8 vs 1.8 h, P <0.01).
European Journal of Clinical Pharmacology.
April 1992, Volume 42, Issue 4, pp 439–443| Cite as.
These changes were initially observed at 0.5 h after dosage and lasted up to 8 h. Pharmacodynamic measures showed that sublingual and oral alprazolam both produced sedation, fatigue, impaired digit symbol substitution, slowing of reaction time, and impairment of the acquisition and recall of information.
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In general the two routes were significantly different from placebo but not from each other.
1 The absorption of single doses of diazepam in six adult epileptic subjects following intravenous, oral and rectal administration were studied in order to evaluate the usefulness of the latter in emergency Get a printable copy (PDF file) of the complete article (597K), or click on a page image below to browse page by page.
3 Two suppository formulations showed statistically significant differences in absorption characteristics. 1 The absorption of single doses of diazepam in six adult epileptic subjects following intravenous, oral and rectal administration were studied in order to evaluate the usefulness of the latter in emergency situations in the adult. 2 Diazepam tablets (Valium, Roche) and rectal solution (Valium solution for intravenous administration) produced similar peak serum concentrations after delays of 15-90 min. 4 Serum diazepam levels above 400 ng ml-1 (suggested to be necessary for a satisfactory anticonvulsant effect) were reached in only a few subjects after rectal doses of 10-20 mg of solution, and then usually after a delay of over 2 h.
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