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Valium and nos


Interaction between nitrous oxide and diazepam in the mouse

3.14.2018 | Andrew Babcock
Valium and nos

The interaction between nitrous oxide and diazepam was assessed in the mouse staircase test. In this paradigm, the numbers of rears (NR) (simultaneous standing on hindlegs and sniffing the air) and steps ascended (NSA) reflect anxiety and locomotor activity, respectively. Antianxiety drugs characteristically reduce NR.

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In this paradigm, the numbers of rears (NR) (simultaneous standing on hindlegs and sniffing the air) and steps ascended (NSA) reflect anxiety and locomotor activity, respectively. In this study, increasing concentrations of nitrous oxide alone produced progressively greater and statistically significant increases in NSA. The interaction between nitrous oxide and diazepam was assessed in the mouse staircase test. With certain combinations of concentration and dose, nitrous oxide enhanced the effect of diazepam on NR without altering NSA. Diazepam alone decreased NR equally and significantly at all doses. These findings suggest that nitrous oxide can increase the antianxiety effect of diazepam without increasing its sedative effect in the mouse staircase paradigm. Nitrous oxide alone had no significant effect on NR until, at a concentration of 75%, it decreased NR. Antianxiety drugs characteristically reduce NR but not NSA, while sedative drugs reduce both NR and NSA in generally parallel fashion.

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7.18.2018 | Isaac Leapman
Valium and nos

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MDMA Ketamine NOS Dihydrocodiene Valium (COMBO)

12.23.2018 | Alexander Brickman
Valium and nos

How safe would it be to consume the following combination - MDMA + Ketamine + NOS + Dihydrocodiene + Valium?? I usually combine all those in a night minus the dihydrocodiene, starting with around 100mg of MDMA with a 70mg redose about an hour later, then snorting ketamine around 4 hours after.

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11.22.2018 | Isaac Leapman
Valium and nos

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