In 1954, Leo Sternbach, a pharmacist and chemist working at the Hoffmann-La Roche pharmaceutical company, was tasked with developing a safer alternative to barbiturates and meprobamate. Over the next few years, Sternbach created about 40 new compounds, but none of them had any effects in animal tests. In 1956.
>100 pills). Such charges for diazepam can result in a fine of $250,000 to $1 million and up to 5 years in prison for a 1st offense. Charges of trafficking (possession with intent to distribute) are brought in cases where an individual is found to be in possession of large quantities of the drug (e.g.
In addition to federal penalties, many states have enacted their own statutes prohibiting the distribution of diazepam and its possession without a legitimate prescription. These state laws can result in additional legal consequences over and above federal penalties.
15, 1963 — the Food and Drug Administration approved Valium. This year, Roche is marking two major milestones: The 40th birthday of its first big-time drug, Valium; and the 95th birthday of the anti-anxiety pill's inventor, Dr. Leo Sternbach. Sternbach still occasionally comes into the office that Roche keeps for him at its.
Ironically Sternbach says his wife never let him pop a Valium after the incident in the lab when he nearly knocked himself out with an overdose of another experimental drug.
It has become much tougher to find compounds that work in new ways, as evidenced by yesterday’s news out of Merck, which is scrapping an ineffective anti-depressant that was in late stage development.
But Valium was not without its downside for Roche. The drug became quite controversial because a lot of people became addicted.
“We have computer modeling.
Leo Sternbach, 97, who created Valium, the nation's most-prescribed drug during the 1970s, until critics claimed it was overused and newer drugs replaced it, died Sept. 28 at his home in Chapel Hill, N.C.. Sternbach became a celebrated figure in research science for his creation of a group of chemicals.
His bosses urged him to forget tranquilizers and move on to antibiotics. With a doctoral degree in organic chemistry from the University of Krakow, he went to work for Hoffmann-LaRoche in Switzerland and came to the United States in 1941, when all the company's Jewish scientists fled Europe at the beginning of World War II. At LaRoche's research facility in Nutley, N.J., he spent two years in the mid-1950s trying, without success, to duplicate Wallace Laboratories' new Miltown tranquilizer.
28 at his home in Chapel Hill, N.C.
Chemist Leo Sternbach works in a lab at Hoffman-La Roche Inc. pharmaceutical company in this company photo from the early 1970s in Nutley, N.J. Sternbach is best known for inventing the tranquilizer drug Valium, which became one of the most prescribed drugs in the U.S. Valium, the drug that.
An Austrian native who said he loved chemistry from his youth, Sternbach led development of more than a dozen important drugs during a six-decade career with Roche. His other breakthroughs include the sleeping pills Dalmane and Mogadon, Klonopin for epileptic seizures and Arfonad for limiting bleeding during brain surgery.
Roche sold nearly 2.3 billion Valium pills stamped with the trademark "V" at the drug's 1978 peak.
He and his wife, Herta, settled in Montclair, near Roche's U.S.
Valium: Valium, trade name of a tranquilizer drug introduced by the pharmaceutical company Hoffmann-La Roche in 1963. Safer and more effective than earlier sedative-hypnotic drugs.
See also diazepam. Safer and more effective than earlier sedative-hypnotic drugs, Valium quickly became a standard drug for the treatment of anxiety and one of the most commonly prescribed drugs of all time. Valium, trade name of a tranquilizer drug introduced by the pharmaceutical company Hoffmann-La Roche in 1963. Its association in the popular mind with harried middle-class housewives won it the nickname “ Mother’s Little Helper” in a 1966 song of that name by the British rock band the Rolling Stones.
It belongs to a group of chemically related compounds (including chlordiazepoxide) called benzodiazepines, the first of which was synthesized in 1933.