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Absorption of diazepam


Diazepam absorption SpringerLink

4.14.2018 | Alexander Brickman

The kinetics of diazepam absorption were assessed in 37 healthy volunteers, aged 19–79 years, who ingested a single 5-mg tablet in the fasting state. Diazepam plasma concentrations were measured by gas chromatography in multiple samples drawn over the next 72 hr. After a lag time averaging 12 min elapsed between.

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Supported in part by grant Oc 10/4 from Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, West Germany; and grants MH-34223 and GM-07611 from the United States Public Health Service.

Digestive Diseases and Sciences.

March 1982, Volume 27, Issue 3, pp 225–230| Cite as.

Thus absorption of oral diazepam in the fasting state is rapid and nearly complete, and is minimally influenced by age, sex, or Billroth gastrectomy.

Absorption of Diazepam from a Lipid-Containing Oral Dosage Form

8.18.2018 | Allison Baldwin
Absorption of diazepam

The drug absorption characteristics of a lipid-containing oral dosage form were studied in human subjects and rats. Diazepam was employed as a model drug and medium-chain triglyceride (MCT) was used as a model lipid. When administered orally to four human subjects, there was no significant difference between.

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After oral administration, the retention of diazepam in the small intestine was quite small compared with that in the stomach, suggesting the importance of the gastric disappearance rate in drug absorption from these preparations. Diazepam was employed as a model drug and medium-chain triglyceride (MCT) was used as a model lipid. The drug absorption characteristics of a lipid-containing oral dosage form were studied in human subjects and rats. When administered orally to four human subjects, there was no significant difference between diazepam soft capsules and tablets in the average plasma levels of the drug, due to a large intersubject variation. The mechanism of this effect was further investigated in the rat model dosing a small amount (2μl/rat) of MCT solution or aqueous suspension. Pharmaceutical Bulletin. However, when administered to an individual subject repeatedly, the soft capsules showed the tendency of faster drug absorption and superior reproducibility in the plasma level-time curve, suggesting a more uniform drug absorption rate compared with the tablets. The gastric drug disappearance rate of MCT solution was faster and significantly less variable than that of the aqueous suspension, which was considered to be the main cause of the more uniform drug absorption rate of the oral diazepam-MCT preparations. It is suggested that diazepam, though it is a weak base, was emptied from the stomach mostly while retained in the lipid, and thus was affected by the movement of MCT in the GI tract.

Author's Organization:Formulation Research Department, Pharmaceuticals, Formulation Research Department, Pharmaceuticals, Formulation Research Department, Pharmaceuticals, Formulation Research Department, Pharmaceuticals, Formulation Research Department, Pharmaceuticals.

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Volume 27 (1979) Issue 5 Pages.

DIAZEPAM ROUTES OF ADMINISTRATION AND RATE OF

10.20.2018 | Isaac Leapman
Absorption of diazepam

In the patients with pre-eclampsia, who were pre-loaded with diazepam, the i.m. route provided much higher plasma diazepam concentrations than did the oral route. This was probably a result of reduced gastric motility and gastric secretion caused by diazepam which affected the absorption of subsequent.

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W. D. STURDEE; DIAZEPAM: ROUTES OF ADMINISTRATION AND RATE OF ABSORPTION: A study of women with pre-eclampsia, BJA: British Journal of Anaesthesia, Volume 48, Issue 11, 1 November 1976, Pages 1091–1096, https://doi.org/10.1093/bja/48.11.1091 Download citation file:.

In the patients with pre-eclampsia, who were pre-loaded with diazepam, the i.m. This was probably a result of reduced gastric motility and gastric secretion caused by diazepam which affected the absorption of subsequent diazepam administered orally, and it is unlikely that pre-eclampsia contributed to these differences. Plasma diazepam concentrations were determined following oral, i.m. administration to a group of pregnant women with pre-eclampsia and a group of normal pregnant women. and i.v. Diazepam concentrations were greater following oral as compared with i.m. administration in the control group, who received a single 5-mg dose, and this confirms previous similar reports. Mist, magnesium trisilicate seemed to improve the rate of absorption of diazepam from the intestine in five patients studied, although this effect is unlikely to have much clinical importance. route provided much higher plasma diazepam concentrations than did the oral route.

Absorption of diazepam from the rectum and its effect on interictal

3.13.2018 | Allison Baldwin
Absorption of diazepam

Epilepsia. 1982 Jun;23(3):323-31. Absorption of diazepam from the rectum and its effect on interictal spikes in the EEG. Milligan N, Dhillon S, Oxley J, Richens A. Rectal administration of several different preparations of diazepam to a group of adult volunteer patients with epilepsy produced variable rates of absorption.

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A highly significant reduction in spike frequency was seen compared with placebo. The effect was most marked 10-20 min after administration of diazepam, when the mean spike count fell to 39 +/- 35 SD percent of the control value (p less than 0.01), and this corresponded with a mean serum diazepam level of 210 +2- 125 ng/ml. Rectal administration of several different preparations of diazepam to a group of adult volunteer patients with epilepsy produced variable rates of absorption. An experimental diazepam "solid solution" suppository was found to have significantly better absorption characteristics compared with the commercially available Valium suppository. Diazepam solution 20 mg was administered rectally in 10 adult epileptic patients with frequent spontaneous interictal spikes in their EEGs. Peak serum concentrations following 10 mg, 20 mg, and 30 mg of diazepam solution were achieved between 13-60 min, 10-120 min, and 30-90 min respectively.

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Absorption of diazepam and its transfer through the blood-brain

12.22.2018 | Allison Baldwin
Absorption of diazepam

J Pharmacol Exp Ther. 1984 Jun;229(3):809-15. Absorption of diazepam and its transfer through the blood-brain barrier after intraperitoneal administration in the rat. Hironaka T, Fuchino K, Fujii T. Unlabeled diazepam of 0.9 mg/kg was administered i.p. to the rat of 21 days of age with a trace amount of [N-methyl-3H].

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A time-dependent change of the rate constants through the blood-brain barrier was suggested from a computer simulation. A two-compartment open model was applied and the absorption and distribution rate constants were distinctly determined on the theoretical basis established in the present study with the aid of a computer. to the rat of 21 days of age with a trace amount of diazepam and the drug concentrations in the blood and the brain tissues were determined at various time intervals. Unlabeled diazepam of 0.9 mg/kg was administered i.p. The specific rate constants for absorption, distribution (k12 and k21) and elimination were 0.158, 0.015 and 0.136 and 0.013/min, respectively. A full description of the drug concentration in the central compartment as a function of time enabled us to calculate directly the transfer rate constants between the blood and the brain (k'12 and k'21), resulting in 4.49 and 2.66/min on the average of the five regions in the brain.