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The current and emerging drug targets are also discussed. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population.
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Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization.
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Sieghart et al (1994) Pharmacology of benzodiazepine receptors: an update. 19 24 PMID:. J.Psychiat.Neurosci.
Our GABA review gives an overview of the structure and function of the GABA receptors, as well as highlighting pharmacological ligands for their study.
A collection of over 250 products for pain research, the guide includes research tools for the study of:
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. PLoS One 40 766 PMID:.
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Ufuk et al (2015) In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383. Pharm Res 32 3937 PMID:.
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Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs.
References are publications that support the products' biological activity.
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Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development.
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Ligand at the GABA A receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus.
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This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target. The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm.
Our Pain guide highlights over 280 products for Pain research.Diazepam